As part of ongoing efforts to reduce waste and increase the reproducibility of animal research and testing, a group of experts led by the Secretary of Norecopa has produced a set of guidelines for planning animal experiments:
PREPARE (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence)
The PREPARE guidelines for planning animal experiments complement the ARRIVE guidelines and other guidance for reporting experiments. PREPARE focuses on a large number of factors which, although they are seldom reported in scientific papers, can dramatically influence the validity and outcome of studies on animals, as well as the health and safety of all those concerned. They cover all stages of quality assurance, from the management of an animal facility or population to the individual procedures which form part of a study. The guidelines and checklist are based upon the authors' experience in running animal facilities, collaborating with researchers (including those working with farm animals, fish and wildlife), serving on advisory and regulatory committees, and planning their own animal studies.
PREPARE is NOT "yet another checklist to prove compliance"!
It is an aide memoire to remind scientists of all the topics which may be relevant when planning experiments, in the same way as even experienced pilots use checklists on routine flights. Many of these topics do not need to be reported, but they are vital for the success of the experiment, for health & safety, and for animal welfare.
The 15 topics in the guidelines, with a large number of links to other more specific guidelines and resources, are discussed under the sections in the menu above. They include a suggestion for a contract between the animal facility and research group, to aid division of labour, costs and responsibility.
A 2-page checklist, available in several languages, can be downloaded free of charge here.
Links to new resources will be added as they are developed.
PREPARE will therefore be a living and dynamic set of guidelines which mirror developments in best practice within the field of research animal science and 3R-alternatives.
Endorsement of PREPARE and other resources
- PREPARE has been endorsed by ANZCCART (Australian and New Zealand Council for the Care of Animals in Research and Teaching)
- PREPARE has been included in the Australian guidance Best Practice Methodology in the Use of Animals for Scientific Purposes, published by the National Health and Medical Research Council (NHMRC) in December 2017.
- PREPARE has been endorsed by Ellegaard Göttingen MInipigs.
- PREPARE was highlighted in the January edition of the newsletter of the National Centre for the 3Rs (NC3RS) in the UK.
- Are you aware of PREPARE? An article by the Swiss 3R network
- PREPARE is highlighted in the paper Promoting and improving 3Rs practice: the Korean guidelines, published in BMB Reports in December 2017
- Improving animal research: PREPARE before you ARRIVE (Letter to the BMJ) (metrics)
Please contact Adrian Smith at Norecopa for more information.
Web-based presentation of PREPARE (with sound):
Planning animal research: PREPARE before you ARRIVE
Powerpoint presentations for free downloading:
PREPARE before you ARRIVE: advice on how to plan animal studies from day one (IAT, Dublin, 23 May 2018)
How to plan animal experiments: PREPARE before you ARRIVE (Scand-LAS 2018)
The PREPARE guidelines for planning animal research and testing
Presentations for Karolinska Institutet (20 March 2018):
PREPARE guidelines (for the Animal Welfare Body)
PREPARE guidelines (for Function B course in Lab Animal Science)
The list of items in PREPARE is offered as a guide and should be adapted to the individual research project, animal species and location. Some elements will be the responsibility of the animal facility itself, rather than the individual research group, since they determine the standard of the facility as a whole. However, a research project often raises questions which are not covered by the facility’s normal work routines. These include activities which have potential health and safety risks, such as the use of micro-organisms, ionising radiation and carcinogens. Early and open dialogue between the facility and research group, to create a good atmosphere for collaboration, is therefore essential. For example, if a facility cannot safely conduct an experiment without structural changes or investment in new equipment, this should be discussed with the research group at an early stage, however tempting it may be to start collaboration on a prestigious project. Animal welfare and ethics committees can be a useful forum for some of this dialogue.
PREPARE: Guidelines for Planning Animal Research and Testing
Adrian J. Smith1, R. Eddie Clutton2, Elliot Lilley3, Kristine E. Aa. Hansen4 & Trond Brattelid5
1Norecopa, c/o Norwegian Veterinary Institute, P.O. Box 750 Sentrum, 0106 Oslo, Norway; 2Royal (Dick) School of Veterinary Studies, Easter Bush, Midlothian, EH25 9RG, U.K.; 3Research Animals Department, Science Group, RSPCA, Wilberforce Way, Southwater, Horsham, West Sussex, RH13 9RS, U.K.; 4Section of Experimental Biomedicine, Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, P.O. Box 8146 Dep., 0033 Oslo, Norway; 5Division for Research Management and External Funding, Western Norway University of Applied Sciences, 5020 Bergen, Norway.
Smith, AJ, Clutton, RE, Lilley, E, Hansen KEAa, Brattelid, T. (2018): PREPARE: Guidelines for planning animal research and testing. Laboratory Animals, 52(2): 135-141. DOI: 10.1177/0023677217724823
The costs of Open Access publication of the PREPARE guidelines and the production of conference posters were kindly provided by the Universities Federation for Animal Welfare (UFAW). The paper was pre-published on 3 August 2017.
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